AP BiologyCommon mistakesMeiosis I splits the pairs, meiosis II the sisters

Meiosis I splits the pairs, meiosis II the sisters

  1. The idea
  2. Predict
  3. See it
  4. Why
  5. Check

The idea

“Meiosis I splits the sister chromatids, then meiosis II separates the homologous pairs.”

Mitosis splits sister chromatids, so it's easy to picture meiosis doing that first. Both orders end in four single-chromatid cells, so the swap is easy to miss.

The short version

The mistake: Meiosis I splits the sister chromatids, then meiosis II separates the homologous pairs.

What's actually true: Meiosis I separates the homologous pairs, and each chromosome keeps its sisters joined. Meiosis II separates the sisters.

  1. In meiosis I, homologs line up as pairs. The spindle pulls the partners to opposite poles, so each cell gets one of each pair.
  2. So meiosis I is the reductional division, from diploid, 2n, to haploid, n. Each chromosome still has two chromatids.
  3. Meiosis II works like mitosis. The sisters separate, giving four haploid cells with one chromatid per chromosome.

On the exam: Meiosis I separates homologs and halves the count. Meiosis II separates sisters.

Every common AP Biology mistake